GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs4141404 | 1 | rs5753543 | chr22:31685458 | C22orf30 | chr22:32072242-32146120:- | -0.21 | -3.89 | 0.000117 | Paclitaxel-induced neuropathy |
| BLCA | cis | rs60843830 | 1 | rs57542652 | chr2:228088 | SH3YL1 | chr2:218138-264810:- | -0.44 | -11.5 | 1.67E-26 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs2076028 | 1 | rs5757141 | chr22:38957483 | JOSD1 | chr22:39081549-39096459:- | -0.23 | -3.85 | 0.000138 | Resting heart rate |
| BLCA | cis | rs5757673 | 1 | rs5757673 | chr22:39837920 | NPTXR | chr22:39214458-39240017:- | -0.24 | -3.93 | 0.000101 | Post bronchodilator FEV1 |
| BLCA | cis | rs5758659 | 1 | rs5758659 | chr22:42622003 | C22orf32 | chr22:42475699-42480287:+ | 0.21 | 5.48 | 7.79E-8 | Cognitive function |
| BLCA | cis | rs5758659 | 1 | rs5758659 | chr22:42622003 | CCDC134 | chr22:42196678-42222303:+ | 0.26 | 4.25 | 2.66E-5 | Cognitive function |
| BLCA | cis | rs5758659 | 1 | rs5758659 | chr22:42622003 | CYP2D6 | chr22:42522502-42526883:- | -0.36 | -7.7 | 1.17E-13 | Cognitive function |
| BLCA | cis | rs5758659 | 1 | rs5758659 | chr22:42622003 | NAGA | chr22:42454339-42466846:- | 0.31 | 5.6 | 4.01E-8 | Cognitive function |
| BLCA | cis | rs5758659 | 1 | rs5758660 | chr22:42623718 | C22orf32 | chr22:42475699-42480287:+ | 0.21 | 5.52 | 6.11E-8 | Cognitive function |
| BLCA | cis | rs5758659 | 1 | rs5758660 | chr22:42623718 | CCDC134 | chr22:42196678-42222303:+ | 0.25 | 4.16 | 3.92E-5 | Cognitive function |
| BLCA | cis | rs5758659 | 1 | rs5758660 | chr22:42623718 | CYP2D6 | chr22:42522502-42526883:- | -0.36 | -7.72 | 1.05E-13 | Cognitive function |
| BLCA | cis | rs5758659 | 1 | rs5758660 | chr22:42623718 | NAGA | chr22:42454339-42466846:- | 0.32 | 5.67 | 2.88E-8 | Cognitive function |
| BLCA | cis | rs5758659 | 1 | rs5758677 | chr22:42643039 | C22orf32 | chr22:42475699-42480287:+ | 0.2 | 5.39 | 1.22E-7 | Cognitive function |
| BLCA | cis | rs5758659 | 1 | rs5758677 | chr22:42643039 | CCDC134 | chr22:42196678-42222303:+ | 0.25 | 4.07 | 5.6E-5 | Cognitive function |
| BLCA | cis | rs5758659 | 1 | rs5758677 | chr22:42643039 | CYP2D6 | chr22:42522502-42526883:- | -0.36 | -7.56 | 2.92E-13 | Cognitive function |